Female Viagra Helps Improve Your Odds With Cardiovascular Risks

When sildenafil, the active component of Female Viagra, appeared on the market, the anecdote blamed it as a dangerous drug for heart patients, more for cultural reasons than for objective data.

Cardiovascular diseases are the leading cause of mortality for the over 50s, overcoming all forms of cancer, including breast cancer. And in addition to the known risk factors, women have specific alarm bells linked to femininity. Against this background, how safe is the use of sildenafil in female population?

Several researches have already documented the favorable effect of phosphodiesterase type 5 inhibitors (PDE5-i) on primary pulmonary hypertension, and suggest potentially favorable effects on a number of other cardiovascular diseases. This is not surprising considering the mechanism of action of these drugs. Not by chance the first experiments carried out on sildenafil investigated its antianginal effect, but the efficacy on the symptom was scarce while the patients showed a peculiar “side effect”.

Sildenafil, the basic ingredient in Female Viagra, was effective for treating heart ‘enlarged’ by cardiomyopathy, preventing heart failure, the cause of death of 80% of diabetics.

This was demonstrated by the group of Italian researchers coordinated by Andrea Lenzi, director of the Section of Medical Physiopathology and Endocrinology at the Department of Experimental Medicine of the University of Rome La Sapienza, and the research has just been published in the journal Circulation.

The study enrolled 59 patients with a mean age of 60 (60.3 ± 7.4 years) with type 2 diabetes and asymptomatic diabetic cardiomyopathy. Their cardiac resonance was in fact compatible with non-ischemic cardiomyopathy (with a reduction of the circumferential strain -12.6 ± 3.1, an increase in left ventricular torsion θ: 18.4 ± 4.6 and an increase in the mass-volume ratio of the left ventricle 2.1 ± 0.5 g / mL) were randomized to receive sildenafil (100 mg daily) or placebo. At baseline, metabolic indices were related to torsion, strain, NT-proBNP, VEGF, MCP1 and arterial pressure levels. After 3 months, patients treated with sildenafil showed a significant improvement over those taking placebo, or compared to left ventricular torsion and strain.

The study concluded that the use of sildenafil in patients with predisposition to cardiac trouble is safe and even beneficial, since at cardiac level, PDE5i would seem to reduce the remodeling induced by pressure overload, while in the vessel wall they could protect from ischemic damage, prevent muscle cell proliferation and thus the organization of atherosclerotic plaque.

Published by Evelyn Green